Principal Investigator

Professor Mark Willcox

Professor Mark Willcox

Principal Investigator

Biography

I am a medical microbiologist who has worked for many years in the area of infections of medical devices. My laboratory focuses on development of novel antimicrobials that have applications as antibiotics and disinfectants. We also develop new antimicrobial coatings that can be used for a variety of purposes, including coating of medical devices to reduce associated infections.

Research Focus
  • Design of novel antimicrobials for use as antibiotics and disinfectants
  • Design and testing of novel antimicrobial surfaces for medical devices
  • Evaluation of the ocular microbiome to ocular surface homeostasis
  • Discovery of biomarkers of human disease from tears
  • Understanding changes to tears during contact lens wear
  • Assessing microbial and mammalian responses during keratitis
Education
  • DSc in ocular surface research (University of New South Wales, 2015)
  • PhD in Medical Microbiology/Dentistry (University of Manchester, 1987)
  • BSc Hons in Applied Biology (University of the West of England, 1983)
Key Achievements
  • Over 550 peer-reviewed publications
  • 15 patents
  • Fellow of the American Academy of Optometry
  • Fellow of the British Contact Lens Association
  • Fellow of the Australian Society for Microbiology
  • Fellow of the Association for Research in Vision and Ophthalmology
Contact

+61-2-9065 5394
m.willcox@unsw.edu.au

School of Optometry and Vision Science
Room 3.004, Rupert Myers Building
UNSW Sydney NSW 2052, Australia

Professional Affiliations
  • Past President of the International Society for Contact Lens Research
  • Member of the Scientific Advisory Board – Ophtecs Corporation
  • Fellow of the American Academy of Optometry (FAAO)
  • Fellow of the British Contact Lens Association (FBCLA)
  • Fellow of the Australian Society for Microbiology
  • Fellow of the Association for Research in Vision and Ophthalmology (ARVO Gold Fellow)

Postdoctoral Researchers

Our experienced research team

Muhammad Yasir

Muhammad Yasir

Senior Research Fellow

antimicrobial peptides; Microbiology; Infections

Umme Laila Urmi

Umme Laila Urmi

Postdoctoral Researcher

Antimicrobial peptide, peptide mimics, antivirals, surface coatings, meibum interaction with drugs

George Enninful

George Enninful

Postdoctoral Researcher

Antimicrobial Peptides; Biological Engineering; Molecular biology

PhD Students

Current doctoral research projects

Abiye Tigabu Molla

Abiye Tigabu Molla

PhD Student

Medical Microbiology, Genomics, molecular biology

Biruk Bayleyegn Belete

Biruk Bayleyegn Belete

PhD Student

Immunohematology; Microbiome

Desie Kasew Assefa

Desie Kasew Assefa

PhD Student

Biofilms

Elias Shiferaw Mekonen

Elias Shiferaw Mekonen

PhD Student

Antimicrobial resistance and novel antimicrobial peptides

Gebreselassie Demeke Mihiretie

Gebreselassie Demeke Mihiretie

PhD Student

Proteins and peptides, Biofilm

Heba Alenezi

Heba Alenezi

PhD Student

Host immune response to microbial keratitis: corneal and conjunctival gene expression, genetics

Jiawei Shen

Jiawei Shen

PhD Student · Dev support engineer

Bacterial infection; Virulence; Biofilm; Antibiotic resistance; Molecular biology; Genomics.

Kuma Diriba Urgeya

Kuma Diriba Urgeya

PhD Student

This study aimed to assess the effects of a single phage, a phage cocktail, and a phageantibiotic combination against P. aeruginosa biofilms isolated from corneal patients

Meseret Alem Damtie

Meseret Alem Damtie

PhD Student

Antibiotic resistance; antimicrobial peptide

Mukesh Kumar

Mukesh Kumar

PhD Student

optometry; contact lens

Nathan Carey

Nathan Carey

PhD Student

My research aims are broadly to synthesise new antimicrobial compounds. Recently my attention has been on using bacterial iron transport mechanisms to target resistant, virulent bacterial strains.

Naveed Saleem

Naveed Saleem

PhD Student

Antimicrobial peptides

Nebiyat Feleke Adimassu

Nebiyat Feleke Adimassu

PhD Student

The role of bacteria in meibomian gland dysfunction

Rasel Ahmed Khan

Rasel Ahmed Khan

PhD Student

My research interests lie in the field of medicinal chemistry, with a particular focus on the design and development of novel therapeutic agents. Currently, I am working on the development of next generation quorum sensing inhibitors.

Samea Khan

Samea Khan

PhD Student

diabetic; Microbiology, Molecular biology

Samuel Attard

Samuel Attard

PhD Student

Synthesis of antimicrobial peptide-mimicking hydrogels

Shakeel Shahzad

Shakeel Shahzad

PhD Student

Resistance of Acinetobacter spp. to Cationic Antimicrobials, and Effects on Virulence

Srikanth Dumpati

Srikanth Dumpati

PhD Student

Optometry; contact lens

Suleman

Suleman

PhD Student

Bacteriophages to control microbial keratitis caused by MDR Pseudomonas aeruginosa

Tanzina Akter

Tanzina Akter

PhD Student

Resistance and virulence characteristics of exoU and exoS Pseudomonas aeruginosa

Teshome Belachew Eshete

Teshome Belachew Eshete

PhD Student

dual-acting antimicrobials

Tope A. Ibisanmi

Tope A. Ibisanmi

PhD Student · Site developer

Antimicrobial resistance

Yalewayker Tegegne Asrat

Yalewayker Tegegne Asrat

PhD Student

Acanthamoeba endosymbionts

Masters Students

Graduate research projects

Lilla Nur Firli

Lilla Nur Firli

Masters Student

Natural products isolation and characterisation of bioactive compounds

Visiting Fellows

Visiting researchers and collaborators

Mahjabeen Khan

Mahjabeen Khan

Visiting Fellow

Microbiology, Antimicrobial resistance, Disinfection testing

Shyam Kumar Mishra

Shyam Kumar Mishra

Visiting Fellow

Antimicrobial resistance, Clinical microbiology, Device-associated infections, Biofilm

Research Staff

Research officers and staff

Hari Kumar peguda

Hari Kumar peguda

Team Member

New ways of diagnosing and treating Acanthamoeba Keratitis

Madeeha Afzal

Madeeha Afzal

Team Member

to track emerging pathogens such as SARS -CoV-2, Mpox and Influenza.

Parthasarathi Kalaiselvan

Parthasarathi Kalaiselvan

Research Officer

My research focuses on advancing eye health through the development of novel antimicrobial strategies and the clinical evaluation of contact lenses. I have a strong interest in antimicrobial peptides and their role in combating antimicrobial resistance, with applications in ocular surface diseases. My work spans laboratory research, animal models, and human clinical trials, integrating cell culture studies with translational applications. In addition, I investigate dry eye disease, ocular surface health, and binocular vision to better understand the complex interactions affecting patient outcomes.

Sidra Sarwat

Sidra Sarwat

Casual Academic

My research focuses on understanding the nanoscale dynamics of the precorneal tear film in dry eye disease by developing and applying fluorescent silicon quantum dots (Si-QDs) as advanced bioimaging probes. By engineering Si-QDs with tailored surface chemistries, ranging from highly hydrophilic groups, I aim to selectively interrogate the interactions, residence time, and turnover of aqueous and lipid tear film layers. Using in vivo rabbit models, the project integrates realtime fluorescence imaging with biocompatibility assessment to quantify tear film stability, lipid layer dynamics, and ocular safety. This work seeks to bridge a critical gap between biochemical tear film alterations and clinical manifestations of dry eye disease, providing a novel nanotechnology based framework for mechanistic understanding and future diagnostic or therapeutic strategies.

Alumni

Former lab members

Margaret Patrikakis

Andrew J. Geyelin

Helen J Oakey

Masahiko Fukuda

Christina Baleriola-Lucas

Fakhry Bestawros

Dr Wylinn Boey

A/Professor Archana Thakur

Julie Wickson

Dr Rebecca Taylor

Dr Kaye Power

Najat Harmis

Alison Clegg

Akta Chauhan

Karen Corrigan

Dr Damon Pearce

Gulhan Demirci

Dr Jai-Min Kim

Dr Sreedharan Athmanathan

Sophie Thuruthyil

Yulina Aliwarga

Jason Kassis

Maxine Tan

Dr Katherine Hollis-Watts

Dr Shamila Khan

Linda Garthwaite

Rani Bandara

Aidong Ding

A/Professor Qian Garrett

Dr Banglao Xu

Dr Zhenjun Zhao

Wen Wang

Dr Carla de Freitas Campos

Dr Ruo Zhong (Tony) Xie

Shamil Iskander

Professor Jingfang Liu

Duojia Wu

Dr Jaya Dantam

Neeta Khandekar

Dr Cameron Postnikoff

A/Professor Maud Gorbet

Dr Keizo Watanabe

Dr Ulrike Hampel

Dr Shashidhar Nizalapur

Dr Aditi Taunk

Bjorn Kamphuis

Rasim Pinarbasi

Franziska Kampshoff

Dr Davood Kharaghani

Dr Kate Browne

Dr Shekh Sabir

Dr Lakshman Subbaraman

Maud Kuipers

Cima Hachem

Research Areas

Our expertise spans multiple disciplines

Ocular Microbiology

Study of microbial communities and infections of the eye

Ocular Microbiome

Analysis of the microbial ecosystem of the ocular surface

Novel Antimicrobials

Development of new antibiotics and disinfectants

Contact Lenses

Research on contact lens materials and comfort

Join Our Research Team

We're always looking for talented researchers, students, and collaborators. Our group offers opportunities for cutting-edge research in ocular microbiology, antimicrobial development, and medical device innovation.